NeuroPrecision Lab

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About NeuroPrecision Lab

NeuroPrecision Lab advances acute stroke and neurovascular care with precision medicine, device innovation, and computational research. As a UPMC Stroke Institute affiliate, our team bridges clinical care, data science, innovation, and machine learning to improve clinical outcomes and reduce disability for patients worldwide.

The Urgent Case for Innovation

0
Million
neurons lost per minute of untreated stroke
0
Million
new strokes annually worldwide
1 in 4
people over 25 will experience stroke
0
Million+
living with stroke consequences
0
Billion
global economic burden annually
Every 4 seconds
a stroke strikes in the U.S.

From evidence to solutions

1
Discover
Questions from the bedside, answered with data: registries, pooled trials and causal models that show where care falls short.
2
Validate
Rigorous testing before anything reaches patients: external validation, multicenter cohorts and randomized trials.
3
Translate
Each result takes the route that fits: a spin-off company, licensing, a service core, or a practice-changing trial. See beyond the lab
4
Scale
Real-world implementation across hospitals and countries, with the evidence to keep improving it.

Beyond the lab

A finding helps patients only once it leaves the lab. We give each solution the vehicle that fits it best: a company, a license, a service core, a validation center or a trial.

Spin-off

HORUS NeuroTechnologies

Our spin-off for digital solutions. A University of Pittsburgh-licensed company developing clinical decision support for acute neurological care, starting with LUCID and TrialLens.

Visit horusneuro.com
Service core

Statistical and Data Science Core Lab

Our service core for multicenter collaborations, open for consultation.

About the core
Validation center

Validation Center

Historic case controls from our registry for matched analyses, and validation of new models, tools and devices in clinical settings.

Work with the center

Our cores

Clinical Trials Unit

Investigator-initiated multicenter trials, led end to end.

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Statistical and Data Science Core Lab

A service core for multicenter collaborations.

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AI and Digital Health

Models and decision support that bring the evidence to the bedside.

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Imaging and Biological Biomarkers

Signals that explain who benefits, and why.

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Medical Device Development

From a bedside problem to a device in a partner's hands.

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Systems of Care and Quality

Faster, fairer access to treatment across a network.

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Building the Next Generation

Capacity building and training through our scholar and research fellowship program.

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Work with a core

Trials, statistics, devices or training: tell us what you need.

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Featured trial

The DUSK Trial

Thrombectomy for distal medium vessel occlusion stroke. A phase III randomized trial, active and enrolling, with up to 50 sites.

About DUSKJoin as a site
  • Phase IIIrandomized 1:1
  • 584patients
  • 50sites, up to

Find your path

Sites

Join the DUSK trial and enroll patients with distal medium vessel occlusion stroke.

Join DUSK

Investigators

Statistical analysis plans, pooled analyses and methods support for your study.

Request a consultation

Leadership

Dr. Mohamed Doheim
Mohamed (Mo) F. Doheim, MD, PhD, FRCP
Founding Director and Principal Investigator
Clinical Research Assistant Professor of Neurology, UPMC Stroke Institute, University of Pittsburgh School of Medicine
Dr. Doheim earned his PhD from Maastricht University and completed the NIH StrokeNet Fellowship at the UPMC Stroke Institute. He was elected a Fellow of the Royal College of Physicians in 2026, and leads the lab's work on individualized treatment, clinical trials and translational innovation.
Pitt profiledoheim.comGoogle Scholar
Dr. Raul Nogueira
Raul G. Nogueira, MD, FAHA, FSVIN
Founding Co-Director and Co-Principal Investigator
Endowed Professor of Neurology and Neurosurgery; Division Chief, Cerebrovascular Medicine; Director, UPMC Stroke Institute
Dr. Nogueira trained at Massachusetts General Hospital and Harvard Medical School, and led the Grady and Emory stroke programs before joining Pitt in 2022. A founder of the Society of Vascular and Interventional Neurology, he has led pivotal thrombectomy trials, including DAWN, BEST, RESILIENT and ATTENTION, and authored more than 700 publications.
Pitt profileGoogle Scholar

Selected Publications

Feasibility of emergent single-step intracranial self-expanding stent deployment using over-the-wire coronary balloons in intracranial atherosclerosis-related large vessel occlusion thrombectomy
Al-Bayati AR, Doheim MF, Mohammaden MH, Lang M, Gross B, Haussen DC, Nogueira RG.
J Neurointerv Surg. 2025
View
Meta-Analysis of Randomized Controlled Trials on IV Thrombolysis in Patients With Minor Acute Ischemic Stroke
Doheim MF, Nguyen TN, Xiong Y, et al.
Neurology. 2025
View
Adjunctive Thrombolytics After Successful Endovascular Reperfusion: A Systematic Review and Meta-Analysis
Doheim MF, Mohammaden MH, Jumah A, et al.
Annals of Neurology. 2025
View
Association of anesthesia strategies with outcomes in endovascular treatment for distal and medium vessel occlusions
Doheim MF, Knapen RR, et al.
European Stroke Journal. 2025
View
Direct Endovascular Versus Bridging Therapy in M2 Segment Occlusion of Middle Cerebral Artery
Doheim MF, Knapen RRMM, et al.
Stroke. 2025
View
Endovascular therapy for acute vertebrobasilar occlusion (VERITAS): a systematic review and individual patient data meta-analysis
Nogueira RG, Jovin TG, Liu X, et al.
The Lancet. 2025
View
Thrombectomy for anterior circulation stroke beyond 6 h from time last known well (AURORA): a systematic review and individual patient data meta-analysis
Jovin TG, Nogueira RG, Lansberg MG, Demchuk AM, Martins SO, Mocco, Ribo M, et al.
Lancet. 2022
View
Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct
Nogueira RG, Jadhav AP, Haussen DC, Bonafe A, Budzik RF, Bhuva P, Yavagal DR, et al.
N Engl J Med. 2018
View
Distal Medium Vessel Occlusion Strokes: Understanding the Present and Paving the Way
Nogueira RG, Doheim MF, et al.
Journal of Stroke. 2024
View
Dr. Nogueira's Scholar Dr. Doheim's Scholar

Get In Touch

Email
info@neuroprecisionlab.org
Address
UPMC Stroke Institute
C-400 PUH
200 Lothrop St
Pittsburgh, PA 15213
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@NeuroprecisionL

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