NeuroPrecision Lab

Research Innovation Pathway

Strategic Discovery

Breakthrough ideas emerging from clinical frontline insights and cutting-edge technology convergence

Validation & Derisking

Rigorous preclinical & clinical validation combined with early-stage data generation and multi-center trial execution

Global Transformation

Real-world implementation, regulatory excellence, and worldwide scale to maximize clinical impact

Lab Domains

Clinical Research Unit

Leading multi-center clinical trials with expertise in proposal development, coordinating center leadership, study design, regulatory management, and execution of complex clinical studies.

Data Science & Statistics

End-to-end data management, global registry coordination, data harmonization, and advanced statistical analysis supporting multi-center research collaborations.

AI & Machine Learning

Developing precision models for acute neurological care, clinician-facing decision support tools, and counterfactual simulations for policy and workflow optimization.

Medical Device Innovation

From concept to commercialization for neurovascular devices, including bench testing, preclinical evaluation, IP strategy, and industry partnerships.

Clinical Quality & Auditing

Benchmarking frameworks, quality registries, continuous improvement cycles, and performance monitoring dashboards for neurovascular care excellence.

Research Training

Structured training programs, mentorship tracks, workshops on trial design and statistics, and global educational initiatives in neurovascular research methods.

Research Impact

Trials to Impact

Conducting groundbreaking clinical trials that directly translate into improved patient outcomes and establish new standards of care.

Data to Insight

Leveraging large-scale data analytics to uncover patterns and insights that drive evidence-based neurological care.

AI to Bedside

Developing and implementing AI-powered tools that enhance clinical decision-making and patient care in real-time.

Innovation to Market

Translating laboratory discoveries into practical solutions that reach patients through commercialization and clinical adoption.

Leadership

Raul G. Nogueira

MD, FAHA, FSVIN

Founding Co-Director, Principal Investigator

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Internationally recognized leader in vascular neurology and neurointervention. Pioneered multiple clinical trials and innovations in stroke care.

Mohamed (Mo) F. Doheim

MD, PhD (c)

Founding Co-Director, Principal Investigator

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Leading innovative research in precision neurological care with a focus on time-sensitive emergencies and advanced clinical interventions.

Selected Publications

Feasibility of emergent single-step intracranial self-expanding stent deployment using over-the-wire coronary balloons in intracranial atherosclerosis-related large vessel occlusion thrombectomy

Al-Bayati AR, Doheim MF, Mohammaden MH, Lang M, Gross B, Haussen DC, Nogueira RG.

J Neurointerv Surg. 2025

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Meta-Analysis of Randomized Controlled Trials on IV Thrombolysis in Patients With Minor Acute Ischemic Stroke

Doheim MF, Nguyen TN, Xiong Y, et al.

Neurology. 2025

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Adjunctive Thrombolytics After Successful Endovascular Reperfusion: A Systematic Review and Meta-Analysis

Doheim MF, Mohammaden MH, Jumah A, et al.

Annals of Neurology. 2025

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Association of anesthesia strategies with outcomes in endovascular treatment for distal and medium vessel occlusions

Doheim MF, Knapen RR, et al.

European Stroke Journal. 2025

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Direct Endovascular Versus Bridging Therapy in M2 Segment Occlusion of Middle Cerebral Artery

Doheim MF, Knapen RRMM, et al.

Stroke. 2025

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Endovascular therapy for acute vertebrobasilar occlusion (VERITAS): a systematic review and individual patient data meta-analysis

Nogueira RG, Jovin TG, Liu X, et al.

The Lancet. 2025

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Thrombectomy for anterior circulation stroke beyond 6 h from time last known well (AURORA): a systematic review and individual patient data meta-analysis

Jovin TG, Nogueira RG, Lansberg MG, Demchuk AM, Martins SO, Mocco J, Ribo M, et al.

Lancet. 2022

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Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct

Nogueira RG, Jadhav AP, Haussen DC, Bonafe A, Budzik RF, Bhuva P, Yavagal DR, et al.

N Engl J Med. 2018

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Distal Medium Vessel Occlusion Strokes: Understanding the Present and Paving the Way

Nogueira RG, Doheim MF, et al.

Journal of Stroke. 2024

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Dr. Nogueira's Scholar Dr. Doheim's Scholar